UPC Cambridge

ISO 13485 | Medical Devices Quality Management | MD 69713

Technology Insights


Live Vaccines

Cold Chain




Dry Powder
Ambient Storage

Inhaled Route?

Single Dose Inhalers

Recombining Syringes






Sterile Products

Vial and Syringe

Auto – Injectors






Vaccines are generally biological products, so not synthetic organic chemicals. Thus they are sensitive to heat degradation and often need cold-chain storage from manufacture to point of delivery. Sterile production methods for cell growth, harvest, inoculation with attenuated virus (as an example) are expensive and difficult to maintain. Sterile filling lines for biologics for injection without air inclusion in the Primary Container is also needed.

The TAP Blosystems fully robotic cellmate® made vaccine was Varivax (Varicella inoculation) for Merch in 1991. 

In 2022 the use of disposable T flasks and disposable roller bottles vaccine manufacture is not ideal in a low-carbon future. 

Marking vaccines is difficult. Stainless steel vessels, controlled temperatures, plumbing and liquids everywhere. 

Covid Vaccines all needed cold chain, one down to -70°C. All covid vaccines were delivered by HCP’s at treatment centres using syringes subQ.

Small molecules, combination treatments, triples, 4 drug systems, soft mist nebuliser, low-gap propellants